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Santa Comba may refer to:
People
- Columba of Sens
- Columba of Spain
- Columba of Cornwall
Places
Portugal
- Santa Comba Dão, a city and municipality
- Santa Comba (Ponte de Lima), a parish in the district of Ponte de Lima
- Santa Comba (Seia), a parish in the district of Seia
- Santa Comba (Vila Nova de Foz Côa), a parish in the district of Vila Nova de Foz Côa
- Santa Comba de Rossas, a parish in the district of Bragança
Spain
- Santa Comba, Galicia, a municipality in A Coruña province, Galicia