Santa Clara is a city in Guadalupe County, Texas, United States. The population was 778 at the 2020 census, up from 725 at the 2010 census. It is part of the San Antonio Metropolitan Statistical Area.
Santa Clara was incorporated as a city in May 1999.
Geography
Santa Clara is located in western Guadalupe County. It is west and north of Marion and east of Cibolo. Seguin, the county seat, is to the east, and downtown San Antonio is to the southwest.
According to the United States Census Bureau, Santa Clara has a total area of , all land.<br>2020 Census
| align-fn = center
2020 census
As of the 2020 census, Santa Clara had a population of 778. The median age was 48.0 years. 18.6% of residents were under the age of 18 and 21.2% of residents were 65 years of age or older. For every 100 females there were 100.0 males, and for every 100 females age 18 and over there were 97.2 males.
0.0% of residents lived in urban areas, while 100.0% lived in rural areas.
There were 286 households in Santa Clara, of which 28.7% had children under the age of 18 living in them. Of all households, 68.5% were married-couple households, 12.2% were households with a male householder and no spouse or partner present, and 16.1% were households with a female householder and no spouse or partner present. About 14.6% of all households were made up of individuals and 5.9% had someone living alone who was 65 years of age or older.
! Race !! Number !! Percent
|-
| White || 591 || 76.0%
|-
| Black or African American || 8 || 1.0%
|-
| American Indian and Alaska Native || 1 || 0.1%
|-
| Asian || 2 || 0.3%
|-
| Native Hawaiian and Other Pacific Islander || 1 || 0.1%
|-
| Some other race || 37 || 4.8%
|-
| Two or more races || 138 || 17.7%
|-
| Hispanic or Latino (of any race) || 196 || 25.2%
|}
2000 census
As of the 2000 census,