As of the census of 2000, there were 395 people, 155 households, and 119 families residing in the town. The population density was . There were 953 housing units at an average density of . The racial makeup of the town was 96.20% White, 0.25% African American, 1.77% Native American, 0.25% Asian, 0.76% from other races, and 0.76% from two or more races.
There were 155 households, out of which 31.6% had children under the age of 18 living with them, 63.2% were married couples living together, 9.0% had a female householder with no husband present, and 22.6% were non-families. 20.0% of all households were made up of individuals, and 8.4% had someone living alone who was 65 years of age or older. The average household size was 2.55 and the average family size was 2.90.
In the town, the population was spread out, with 25.1% under the age of 18, 4.3% from 18 to 24, 23.5% from 25 to 44, 31.1% from 45 to 64, and 15.9% who were 65 years of age or older. The median age was 43 years. For every 100 females, there were 110.1 males. For every 100 females age 18 and over, there were 105.6 males.
The median income for a household in the town was $42,083, and the median income for a family was $45,750. Males had a median income of $30,000 versus $24,688 for females. The per capita income for the town was $19,683. About 8.3% of families and 7.4% of the population were below the poverty line, including 10.5% of those under age 18 and 6.6% of those age 65 or over.
Communities and locations in Santa Clara
thumb|View from Long Pond Mountain of waters of the St. Regis Canoe Area (with the [[Adirondack High Peaks|High Peaks in the background)]]
- Bay Pond – A hamlet in the south-central part of the town. It was a former Rockefeller summer home.
- Brandon – A former community, located north of Bay Pond. It became part of the Rockefeller estate and its buildings were removed.
- Derrick – A hamlet west of Saranac Inn.
- Everton – A former community, abandoned after the forests had been stripped.
- Floodwood – A hamlet west of Saranac Inn near the western town line.
- Kildare – A hamlet west of Saranac Inn near the western town boundary.
- Madawaska – A hamlet near the eastern town line.
- Madawaska Pond – A lake near the center of the town.
- Middle Saranac Lake – Part of the lake is in the southeastern corner of the town.
- Meno – A location northeast of Madawaska.
- The Saint Regis Canoe Area – A wilderness area with 58 ponds (no motorized vehicles are allowed).
- Santa Clara – the hamlet of Santa Clara is near the western town line in the northern part of the town on NY-458.
- Saranac Inn (also "Upper Saranac") – A hamlet in the southern part of the town.
- Saranac Inn Station – A location east of Saranac Inn.
- Spring Cove – A hamlet near the western town boundary, south of Santa Clara village.
- Upper Saranac Lake – Most of the lake is in the southern part of the town.
- Weller Pond – A large pond in the southern part of the town.