The Sandyford murder case (also known as the Sandyford Place Mystery) is a well-known 19th-century case from the United Kingdom. The murder in question is one of four notorious ones that took place in an infamous area of Glasgow known as the Square Mile of Murder, which lies around Charing Cross, "situated where Sauchiehall Street is coming to an end as a shopping centre and giving way to well-built terraces". The Sandyford case revolves around the brutal murder of one Jessie McPherson, a servant, at 17 Sandyford Place, Glasgow, Scotland, in July 1862. McPherson's friend Jessie McLachlan later stood trial, accused of having murdered McPherson.
The Sandyford case was the first Scottish police case in which forensic photography played a role, and the first case handled by the detective branch of the Glasgow Police.
The case was heard at the Glasgow Circuit Court between Wednesday 17 and Saturday 20 September 1862. During the trial, McLachlan resolutely declared her innocence, and accused the father of the woman's employer, one James Fleming, age 87, of having committed the crime, perhaps in a fit of passion when McPherson refused his amorous advances. The summing-up of the evidence, delivered by Judge Lord Deas, lasted for more than four hours and, after nineteen minutes' deliberation, the jury returned a unanimous guilty verdict. Before sentence was passed, a final statement was read on behalf of the prisoner, giving her detailed account of what had happened on the night of the murder.