San Tomé may refer to:
- Rotonda di San Tomè, a church in northern Italy
- San Tomé, Venezuela, a town in Anzoátegui, Venezuela
- San Tomé de Angostura, one of the original names of the city Ciudad Bolivar, Venezuela
- São Tomé and Príncipe, an island nation in the Gulf of Guinea
- São Tomé Island, one of two islands and provinces in nation of São Tomé and Príncipe
- São Tomé, the capital city of the island and province of São Tomé