San Manuel may refer to the following:
Places
;Argentina
- San Manuel, Buenos Aires, a settlement in Lobería Partido
;Honduras
- San Manuel, Cortés
;Philippines
- San Manuel, Isabela
- San Manuel, Pangasinan
- San Manuel, Tarlac
;United States
- San Manuel, Arizona
People
- San Manuel Band of Mission Indians, a Serrano tribe in southern California