San Manuel may refer to the following:

Places

;Argentina

  • San Manuel, Buenos Aires, a settlement in Lobería Partido

;Honduras

  • San Manuel, Cortés

;Philippines

  • San Manuel, Isabela
  • San Manuel, Pangasinan
  • San Manuel, Tarlac

;United States

  • San Manuel, Arizona

People

  • San Manuel Band of Mission Indians, a Serrano tribe in southern California