Sakuma (written: 佐久間) is a Japanese surname. Notable people with the surname include:
- , Japanese video game designer
- , Japanese-American retired ice hockey player
- , Japanese idol, tarento, actor, member of boy band Snow Man
- , Japanese photographer
- , Japanese weightlifter
- , Japanese voice actress
- , prominent Oda retainer, cousin of Nobumori Sakuma
- , Japanese samurai who served Oda Nobunaga
- , retainer of the Oda clan, cousin of Morimasa Sakuma
- , Japanese actress, voice actress, singer, narrator
- , Japanese professional footballer
- Roy Sakuma (born 1948), Hawaiian ukulele teacher and founder of the Ukulele Festival
- , Imperial Japanese Army general
- , Japanese former football player and manager
- , Japanese politician and scholar of the Edo period
- , Japanese former professional drifting driver
- , Imperial Japanese Navy career naval officer
- , Japanese actress
- , Japanese actress and model
Fictional characters
- Ryuichi Sakuma, a character in the anime and manga series Gravitation
- Kotaro Sakuma, a character in the Uchu Sentai Kyuranger
- Sakuma Kichiro, a character in Age of Empires III: The Asian Dynasties campaign and main protagonist of the Japanese campaign
- Sakuya Sakuma (佐久間 咲也), a character in A3!
- Sakuma Rei and Sakuma Ritsu from Ensemble Stars!
See also
- 6809 Sakuma, asteroid
- Sakuma Dam
- Sakuma HVDC Back-to-Back Station
- Sakuma drops, a brand for hard candies
- Sakuma, Shizuoka, a town