Sakamoto (written: ) is the 40th most common Japanese surname. A less common variant is .
Notable people with the surname include:
- Chika Sakamoto (born 1959), voice actor and singer
- Fuyumi Sakamoto (born 1967), enka singer
- , Japanese professional baseball player
- Hideki Sakamoto (born 1972), video game composer
- , Japanese swimmer
- Kaori Sakamoto (born 2000), Japanese figure skater
- Kazma Sakamoto (born 1982), Japanese professional wrestler
- , Japanese swimmer
- Kerri Sakamoto (born 1960), Canadian novelist
- , Japanese footballer
- , gymnast
- Kyu Sakamoto (1941–1985), pop singer well known for his song "Sukiyaki" in the 1960s
- Maaya Sakamoto (born 1967), voice actor and singer
- Miu Sakamoto (born 1980), pop singer, daughter of Ryuichi Sakamoto
- , military leader prior to the Meiji Restoration
- Ryuichi Sakamoto (1952–2023), musician and composer, as well as an actor
- , Japanese baseball player
- , Japanese water polo player
- Shōgo Sakamoto (born 1993), actor and singer
- Soichi Sakamoto (1921–2012), American swimming coach
- , Japanese high jumper
- , Japanese freestyle skier
- , Japanese footballer
- , Japanese sprint canoeist
- Yoshio Sakamoto (born 1959), game designer for Nintendo
- The victims of the Sakamoto family murder perpetrated by members of the Aum Shinrikyo cult
Fictional characters
- Sakamoto (Maison Ikkoku), from Maison Ikkoku
- Sakamoto-san, a talking cat from Nichijou
- Sakamoto from Haven't You Heard? I'm Sakamoto
- Akira Sakamoto, and Harumi Sakamoto from Princess Princess
- Chiyo Sakamoto from Memoirs of a Geisha
- Julietta Sakamoto from Air Master
- Ryōta Sakamoto (坂本 竜太), the main character in the manga series Btooom! (ブトゥーム!)
- Sue, her brother Kazuma, and their mother Momorin Sakamoto from Cave Story
- Mio Sakamoto, from Strike Witches
- , the main character in the 2002 South Korean science fiction film 2009: Lost Memories
- Ryuji Sakamoto, from Persona 5
- Taro Sakamoto, from Sakamoto Days
- Tatsuma Sakamoto, from Gintama