STS-58 was a NASA mission flown by Space Shuttle Columbia launched from Kennedy Space Center, Florida, on October 18, 1993. The missions was primarily devoted to experiments concerning the physiological effects in space. This was the first in-flight use of the "Portable In-flight Landing Operations Trainer" (PILOT) simulation software. It was also the last time Columbia would land at Edwards Air Force Base, California. The mission also attracted controversy for experiments involving the dissection of live rats in space.
Crew
Crew seat assignments
{| class="wikitable" style="text-align:center"
! Seat
! Launch
! Landing
|rowspan=8| 150px<br />Seats 1–4 are on the flight deck.<br />Seats 5–7 are on the mid-deck.
|-
! 1
|colspan=2| Blaha
|-
! 2
|colspan=2| Searfoss
|-
! 3
| Seddon
| Wolf
|-
! 4
|colspan=2| McArthur
|-
! 5
| Wolf
| Seddon
|-
! 6
|colspan=2| Lucid
|-
! 7
|colspan=2| Fettman
|}
Mission highlights
thumb|upright=1.0|left|Columbia on Pad 39B