The Southern Poverty Law Center (SPLC) is an American nonprofit civil rights organization.

SPLC may also refer to:

  • Mariano Melgar Airport, Arequipa department of Peru (ICAO code: <code>SPLC</code>)
  • Software Product Line Conference, an annual international conference
  • Student Press Law Center, an American nonprofit journalism organization headquartered in Washington, D.C.
  • Standard Point Location Code, a 9-digit geographic code used by North American transportation industries
  • St Peter's Lutheran Church, Hobart, Australia
  • St Peters Lutheran College, in Brisbane, Australia