SMAD may refer to:
- Soviet Military Administration in Germany, government of the Soviet occupation zone of Germany from May 1945 to October 1949
- Solvated metal atom dispersion, a method of producing nanoparticles
- SMAD (protein), proteins involved in cell signaling
- I-SMAD, inhibitory SMAD proteins
- R-SMAD, receptor regulated SMAD proteins
- Smad, Syria, a village in southern Syria