SLE may refer to:
Medicine
- Systemic lupus erythematosus, an autoimmune disease
- St. Louis encephalitis, a mosquito-borne disease
Science and mathematics
- Semiconductor luminescence equations
- Sea level equation, following post-glacial rebound
- Schramm–Loewner evolution in statistical mechanics
Transportation
- McNary Field, airport in Salem, Oregon, US, IATA code
- Seletar Expressway, Singapore
- Sleeper Either Class, a type of railway car
- Shore Line East commuter rail service in Connecticut, USA
Other
- Sara Lee Corporation, NYSE symbol
- Separate legal entity in US
- Single loss expectancy for risk on an asset
- Societas Linguistica Europaea, a linguistics society
- Sri Lankan English
- Sierra Leone, ISO-3166-1 alpha-3 country code
- Sierra Leonean leone currency code
- Spearhead Land Element of UK armed forces
- Supported leading edge kite, a type of power kite
- SUSE Linux Enterprise
- Sensory Logical Extrovert in socionics
- The Space Link Extension of CCSDS