Rufinus may refer to:
- Saints Rufinus, eleven saints named Rufinus in Roman Martyrology, including:
- Rufinus of Assisi, 3rd-century saint and martyr
- Valerius and Rufinus (d. 287), Christian martyrs
- Rufinus (Roman governor), 3rd century governor of Roman Britain
- Rufinus (consul) (c. 335–395), Eastern Roman statesman
- Tyrannius Rufinus of Aquileia (c. 340–410), Roman monk, historian, and translator
- Rufinus (relative of Theodosius II), 5th century
- Rufinus (poet) of the Greek Anthology
- Rufinus (decretist), 12th-century canon lawyer
- Rufinus Widl (1731–1798), Benedictine monk
- Rufinus (Byzantine official) 5th/6th-centuries Byzantine military officer and emissary
- Lucius Duccius Rufinus, a 1st century standard bearer of the 9th Legion
See also
- Rufino (disambiguation)