Reginald Frederick Wightman (May 28, 1899 – January 23, 1981) was a politician in Manitoba, Canada. He served in the Legislative Assembly of Manitoba as a Liberal-Progressive from 1949 to 1958.
Wightman was born in Nesbitt, Manitoba. He was educated at Manitoba University, which later became the University of Manitoba. He worked as a pharmacist, and was the owner and operator of several pharmacies in the Winnipeg area. He began his political career at the municipal level, serving as chair of the St. James School Board for four years, and as a councillor for six years. Wightman became Mayor of St. James in 1945, and continued to serve as the mayor of the suburb even after his election to the provincial legislature. In 1928, he married Alice Maud Thring.
He died in Winnipeg at the age of 81.
His son, Reginald C. Wightman, is also a public figure in Winnipeg.