thumb|right|Victorian silver mounted rabbit's foot charm

In some cultures, a rabbit's foot is carried as an amulet believed to bring good luck. This belief is held by people in a great number of places around the world, including Europe, Africa, Australia and North and South America. In variations of this superstition, the rabbit it came from must possess certain attributes, such as having been killed in a particular place, using a particular method, or by a person possessing particular attributes (e.g., by a cross-eyed man).

It has been suggested by Benjamin Radford that the rabbit's foot could be connected to a European good luck charm called the Hand of Glory, a hand cut from a hanged man and then pickled.

In North American culture

The belief in North American folklore may originate in the system of folk magic known as "hoodoo". A number of strictures attached to the charm are now observed mostly in the breach, namely that it must be the left hind foot of a rabbit which was shot or otherwise captured in a cemetery. Some sources tell that the rabbit must be taken by the full moon, and others specifying the new moon. Some say instead that the rabbit must be taken on a Friday, or a rainy Friday, or Friday the 13th. Some sources say that the rabbit should be shot with a silver bullet, while others say that the foot must be cut off while the rabbit is still alive.

The various rituals suggested by the sources, though they differ widely one from another, share a common element of the uncanny, and the reverse of what is considered good-omened and auspicious. A rabbit is an animal into which shapeshifting witches such as Isobel Gowdie claimed to be able to transform themselves. Witches were said to be active at the times of the full and new moons.

thumb|325px|The cover to "Rabbit Foot Blues", a [[blues song by Blind Lemon Jefferson, links the rabbit's foot tradition with the bones of the dead.]]

These widely varying circumstances may share a common thread of suggestion that the true lucky rabbit's foot is actually cut from a shapeshifted witch. The suggestion that the rabbit's foot is a substitute for a part from a witch's body is corroborated by other folklore from hoodoo. Willie Dixon's song "Hoochie Coochie Man" mentions a "black cat bone" along with his mojo and his John the Conqueror: all are artifacts in hoodoo magic. Given the traditional association between black cats and witchcraft, a black cat bone is also potentially a substitute for a human bone from a witch. Hoodoo lore also uses graveyard dust, soil from a cemetery, for various magical purposes. Dust from a good person's grave keeps away evil; dust from a sinner's grave is used for more nefarious magic. The use of graveyard dust may also be a symbolic appropriation of the parts of a corpse as a relic, and a form of sympathetic magic. Other newspaper stories reported the incident, but omitted the detail about the rabbit's foot.

In addition to being mentioned in blues lyrics, the rabbit's foot is mentioned in the American folk song "There'll Be a Hot Time in the Old Town Tonight", once popular in minstrel shows; one line goes: "And you've got a rabbit's foot To keep away de hoo-doo".

A related good luck ritual in Britain and the United States is to say "rabbit rabbit rabbit" upon waking on the first day of a month, to bring good luck over the remainder of that month.