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RLS may refer to:
Education
- Royal Latin School, a grammar school in Buckingham, England
- Stevenson School, formerly Robert Louis Stevenson School, California
Science and technology
- Recursive least squares filter, in minimisation
- Regularized least squares, for solving least-squares problems
- Reef Life Survey, a marine monitoring program in Tasmania
- Restless legs syndrome, a medical disorder
Other uses
- Real-life slash, a subgenre of real person fiction
- Rial (disambiguation), plural abbreviation Rls, Middle Eastern currency units
- Robert Louis Stevenson, Scottish writer