RDB may refer to:
Computing
- Amiga rigid disk block, describing partition information
- Oracle Rdb, a relational database product
- Relational database
Military
- Cordite RDB, an experimental form of explosive developed for use by the Royal Navy in World War I
- Kel-Tec RDB, a semi-automatic carbine chambered for 5.56×45mm NATO rounds
Other
- RDB (band) (RDB Rhythm Dhol Bass), a UK music production group
- Richard Doll Building, located in Oxford, England
- State Security Service (RDB), Serbian secret police