The R75 is a provincial route in Eastern Cape, South Africa that connects Graaff-Reinet with Gqeberha via Despatch, Kariega and Jansenville.

Route

Nelson Mandela Bay

The R75 begins at the intersection with the R102 (Govan Mbeki Road) in Sydenham, just north of the Gqeberha city centre as a dual-carriage roadway and heads in a north-westerly direction as Commercial Road. It intersects with the N2 highway in the suburb of Korsten and after crossing the N2, it becomes Uitenhage Road.