The R45 is a provincial route in Western Cape, South Africa that connects Saldanha with Villiersdorp via Vredenburg, Malmesbury and Paarl. The route is mostly a two-lane wide-shouldered highway, however sections within Paarl and between Vredenburg and Saldanha are dual-carriageways. The R45 is co-signed with the N7 for a short segment north of Malmesbury.
Route
The north-western terminus of the R45 is in Saldanha on the West Coast. The route initially heads north-north-east for twelve kilometres to Vredenburg. Here, it reaches a four-way intersection where the straight road becomes the R399 and the road to the left heads north-west to Paternoster, with the R45 becoming the road to the right. Exiting Vredenburg to the east-south-east, the R45 runs for nine kilometres before crossing the R27. After another seven kilometres, the route passes through Langebaanweg. Running 22 kilometres further on, the route passes through Hopefield. After another 14 kilometres, the R311 branches off to the left, heading east to Moorreesburg. The next intersection, after ten kilometres, is with the R307, branching to the south-west to Darling. The R45 continues for a further 31 kilometres to meet the N7.