The R390 is a Regional Route in South Africa that connects Cradock with Bethulie via Hofmeyr, Steynsburg and Venterstad.

Part of the route from Oviston (Gariep Dam) to Cradock forms part of the shortest road route from Johannesburg to Gqeberha.

Route

thumb|220px|left|The R390 between [[Venterstad and Steynsburg]]The R390 begins in Nxuba (formerly known as Cradock) at an intersection with the R61 route and the N10 national route, just east of the N10's Great Fish River crossing. It heads north as Stockenstroom Street, then Deary Avenue, then Ziervogel Street, then Hofmeyr Road, to leave the town. It heads northwards for 63 kilometres to reach an intersection with the R401 route in the town of Hofmeyr. It joins the R401 eastwards up to the second junction, where it becomes Van Heerden Street northwards.