The R345 is a Regional Route in South Africa that connects the R72 near Bell in the Ngqushwa Local Municipality with Cathcart
passing through Peddie, the Great Fish River Nature Reserve, Alice and Hogsback. It is co-signed with the R63 between Alice and Fort Hare. In the eighties, the route started in Hamburg; however, this section is no longer part of the R345 by 2012. and the R345 starts at the intersection with the R72.