The R330 is a Regional Route in South Africa that connects Cape St. Francis on the south coast with Hankey to the north via Humansdorp.
Route
left|thumb|300px|[[Aloe plants along the R330 near Hankey]]
Its northern origin is an intersection with the R331 at Hankey. The route heads south-south-west. Just before reaching the N2 it meets the southern origin of the R332. Crossing the N2, it reaches Humansdorp, where it meets the R102 at a staggered interchange. It then heads south, past St. Francis Bay to end at the village of Cape St. Francis.
