The province of Ascoli Piceno () is a province in the Marche region of Italy. Its capital is the city of Ascoli Piceno, and the province is bordered by the Adriatic Sea to the east, the province of Fermo to the north, and it faces the regions of Umbria and Abruzzo to the south. The province contains 33 comuni (: comune). The population of the province is mostly located in the capital Ascoli Piceno, in the coastal areas and in the city of San Benedetto del Tronto, which has a population of 47,075; the province has a total population of 201,462 as of 2023.
The first settlers of the province were located on the banks of River Tronto by the Picentes tribe. It was later conquered by the Romans and became known as Asculum Picenum by 268 BCE.