Prince of Wales Island may refer to:
; Australia
- Prince of Wales Island (Queensland) one of the Torres Strait Islands in Queensland, Australia
;Canada
- Prince of Wales Island (Nunavut), Canada, part of the Arctic Archipelago
- Prince of Wales Island, Lake Nipigon, Ontario
;Malaysia
- Penang Island, Malaysia, formerly Prince of Wales Island
;USA
- Prince of Wales Island (Alaska), USA
- Prince of Wales Island, Jamaica Bay, New York
See also
- Wales Island (disambiguation)