Poughkeepsie is a city in Dutchess County, New York, United States.
Poughkeepsie can also refer to:
- Relating to Poughkeepsie, New York:
- Poughkeepsie (Metro-North station), a railroad station in the city
- Poughkeepsie (town), New York, a town surrounding the city
- The Poughkeepsie Tapes, a 2007 film based in and named after the aforementioned city.
- Poughkeepsie, Arkansas, an unincorporated area in Sharp County, Arkansas