Pope Sixtus or Xystus is the name of five Popes of the Catholic Church:

  • Pope Sixtus I (saint; ca. 115/119–ca. 125/128)
  • Pope Sixtus II (saint; 257–258)
  • Pope Sixtus III (saint; 432–440)
  • Pope Sixtus IV (1471–1484)
  • Pope Sixtus V (1585–1590)