Pauson–Khand reaction

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The Pauson–Khand (PK) reaction is a chemical reaction, described as a [[Woodward–Hoffmann rules|<nowiki>[</nowiki><nowiki>2+2+1]</nowiki>]] cycloaddition. In it, an alkyne, an alkene, and carbon monoxide combine into a α,β-cyclopentenone in the presence of a metal-carbonyl catalyst

Ihsan Ullah Khand (1935–1980) discovered the reaction around 1970, while working as a postdoctoral associate with Peter Ludwig Pauson (1925–2013) at the University of Strathclyde in Glasgow. Pauson and Khand's initial findings were intermolecular in nature, but the reaction has poor selectivity. Some modern applications instead apply the reaction for intramolecular ends.

The traditional reaction requires a stoichiometric amounts of dicobalt octacarbonyl, stabilized by a carbon monoxide atmosphere. Catalytic metal quantities, enhanced reactivity and yield, or stereoinduction are all possible with the right chiral auxiliaries, choice of transition metal (Ti, Mo, W, Fe, Co, Ni, Ru, Rh, Ir and Pd), and additives.

Mechanism

While the mechanism has not yet been fully elucidated, Magnus' 1985 explanation is widely accepted for both mono- and dinuclear catalysts, and was corroborated by computational studies published by Nakamura and Yamanaka in 2001. The reaction starts with dicobalt hexacarbonyl acetylene complex. Binding of an alkene gives a metallacyclopentene complex. CO then migratorily inserts into an M-C bond. Reductive elimination delivers the cyclopentenone. Typically, the dissociation of carbon monoxide from the organometallic complex is rate limiting.

[[File:Mech_PKR.png|center|thumb|473x473px|<dl>

<dt>1:</dt><dd>Alkyne coordination, insertion and ligand dissociation to form an 18-electron complex;</dd>

<dt>2:</dt><dd>Ligand dissociation to form a 16-electron complex;</dd>

<dt>3:</dt><dd>Alkene coordination to form an 18-electron complex;</dd>

<dt>4:</dt><dd>Alkene insertion and ligand association (synperiplanar, still 18 electrons);</dd>

<dt>5:</dt><dd>CO migratory insertion;</dd>

<dt>6, 7:</dt><dd>Reductive elimination of metal (loss of [Co2(CO)6]);</dd>

<dt>8:</dt><dd>CO association, to regenerate the active organometallic complex.</dd>

</dl>]]

Selectivity

The reaction works with both terminal and internal alkynes, although internal alkynes tend to give lower yields. The order of reactivity for the alkene is<blockquote>(strained cyclic) > (terminal) > (disubstituted) > (trisubstituted).</blockquote> Tetrasubstituted alkenes and alkenes with strongly electron-withdrawing groups are unsuitable.

With unsymmetrical alkenes or alkynes, the reaction is rarely regioselective, although some patterns can be observed.

center|thumb|467x467px|The PK reaction has poor regioselectivity with monosubstituted alkenes. [[Phenylacetylene and 1-octene produce at least 4 isomeric products. ("tol" = toluene)]]

For mono-substituted alkenes, alkyne substituents typically direct: larger groups prefer the C2 position, and electron-withdrawing groups prefer the C3 position.

center|thumb|472x472px|An electron-withdrawing group (ethyl benzoatyl) prefers the C3 position. ("Tol" = [[toluene)]]

But the alkene itself struggles to discriminate between the C4 and C5 position, unless the C2 position is sterically congested or the alkene has a chelating heteroatom.

The reaction's poor selectivity is ameliorated in intramolecular reactions. For this reason, the intramolecular Pauson-Khand is common in total synthesis, particularly the formation of 5,5- and 6,5-membered fused bicycles.

alt=An intramolecular Pauson-Khand reaction|center|frameless|451x451px

Generally, the reaction is highly syn-selective about the bridgehead hydrogen and substituents on the cyclopentane.

alt=An intramolecular Pauson-Khand reaction produces a bicycle with 97% syn to the bridgehead and 3% anti.|center|frameless|474x474px

Appropriate chiral ligands or auxiliaries can make the reaction enantioselective (see ). BINAP is commonly employed.

Additives

alt=Pauson-Khand in DME (dimethoxyethane? dimethyl ether?) at 120°C|center|frameless|545x545px

Typical Pauson-Khand conditions are elevated temperatures and pressures in aromatic hydrocarbon (benzene, toluene) or ethereal (tetrahydrofuran, 1,2-dichloroethane) solvents. These harsh conditions may be attenuated with the addition of various additives.

alt=Original reaction: 24 hours at 60°C with 30% yield. Dry reaction: silica, oxygen, 45°C for 0.5 hours for 75% yield.|left|thumb|390x390px|Adding silica improved this reaction rate by a factor of ≈50.

Absorbent surfaces

Adsorbing the metallic complex onto silica or alumina can enhance the rate of decarbonylative ligand exchange as exhibited in the image below. This is because the donor posits itself on a solid surface (i.e. silica). Additionally using a solid support restricts conformational movement (rotamer effect).

Lewis bases

Traditional catalytic aids such as phosphine ligands make the cobalt complex too stable, but bulky phosphite ligands are operable.

alt=Reaction in cyclohexanamine fails to proceed, but with neo-butyl methyl sulfide it runs to 79% yield.|thumb|392x392px

Lewis basic additives, such as n-BuSMe, are also believed to accelerate the decarbonylative ligand exchange process. However, an alternative view holds that the additives make olefin insertion irreversible instead. Sulfur compounds are typically hard to handle and smelly, but n-dodecyl methyl sulfide and tetramethylthiourea do not suffer from those problems and can improve reaction performance.

Amine N-oxides

The two most common amine N-oxides are N-methylmorpholine N-oxide (NMO) and trimethylamine N-oxide (TMANO). It is believed that these additives remove carbon monoxide ligands via nucleophilic attack of the N-oxide onto the CO carbonyl, oxidizing the CO into CO2, and generating an unsaturated organometallic complex. This renders the first step of the mechanism irreversible, and allows for more mild conditions. Hydrates of the aforementioned amine N-oxides have similar effect.

center|thumb|391x391px|NMO = [[N-Methylmorpholine N-oxide|Nmethylmorpholine Noxide, DCM = dichloromethane]]

N-oxide additives can also improve enantio- and diastereoselectivity, although the mechanism thereby is not clear.

center|thumb|430x430px|(NMO = [[N-Methylmorpholine N-oxide|Nmethylmorpholine Noxide, DCM = dichloromethane)

A step in the total synthesis of epoxydictymene: temperature and ultrasound failed to improve the d.r. for the desired diastereomer (the red hydrogen). But the N-oxide additive, while lower yielding, gave a d.r. of 11:1. although Takayama et al detail a reaction catalyzed by dicobalt octacarbonyl.

center|thumb|736x736px|The key step in Takayama et al<nowiki/>'s [[Asymmetric synthesis|asymmetric total synthesis of the Lycopodium alkaloid huperzine-Q: Co2(CO)8 catalyzes an enyne cyclization. that only a single product enantiomer forms.

Other metals

catalyst requires a silver triflate co-catalyst to effect the Pauson–Khand reaction:

center|407x407px|PK reaction with Wilkinson's catalyst

Molybdenum hexacarbonyl is a carbon monoxide donor in PK-type reactions between allenes and alkynes with dimethyl sulfoxide in toluene. Titanium, nickel, and zirconium complexes admit the reaction. Other metals can also be employed in these transformations.

Substrate tolerance

In general allenes, support the Pauson–Khand reaction; regioselectivity is determined by the choice of metal catalyst. Density functional investigations show the variation arises from different transition state metal geometries.

alt=PK reaction with molybdenum hexacarbonyl|center|thumb|363x363px|Molybdenum catalyzes a Pauson-Khand reaction at an allene's internal double bond. Rhodium would catalyze a reaction at this substrate's terminal double-bond instead.

Heteroatoms are also acceptable: Mukai et al<nowiki/>'s total synthesis of physostigmine applied the Pauson–Khand reaction to a carbodiimide.

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Cyclobutadiene also lends itself to a <nowiki>[</nowiki>2+2+1] cycloaddition, although this reactant is too active to store in bulk. Instead, cyclobutadiene is generated in situ from decomplexation of stable cyclobutadiene iron tricarbonyl with ceric ammonium nitrate (CAN).

center|415x415px|Pauson Khand reaction Seigal 2005

An example of a newer version is the use of the chlorodicarbonylrhodium(I) dimer, [(CO)2RhCl]2, in the synthesis of (+)-phorbol by Phil Baran. In addition to using a rhodium catalyst, this synthesis features an intramolecular cyclization that results in the normal 5-membered α,β-cyclopentenone as well as 7-membered ring.

Carbon monoxide generation in situ

The cyclopentenone motif can be prepared from aldehydes, carboxylic acids, and formates. These examples typically employ rhodium as the catalyst, as it is commonly used in decarbonylation reactions. The decarbonylation and PK reaction occur in the same reaction vessel.