PSB may refer to:
Education
- Paris School of Business, a private business school located in Paris
- Penn State Behrend, a commonwealth Pennsylvania State University campus in Erie, PA.
- Public Schools Branch, the English school district of Prince Edward Island, Canada
- Public Schools of Brookline, a school district of Brookline, Massachusetts, United States
Music
- Pet Shop Boys, an English musical duo
- Plus-Tech Squeeze Box, a Japanese Shibuya-kei band
- PSB Speakers, a Canadian loudspeaker company
- Public Service Broadcasting (band), a British electronic trio
Organisations
- Brunei History Centre (), a government body in Brunei
- Pacific Symposium on Biocomputing, an annual scientific meeting
- Philippine Savings Bank
- Promsvyazbank, a Russian state-owned bank
- PS Business Parks, an American real estate investment trust (NYSE: PSB)
- PSB Insights, a market research firm (Penn Schoen Berland)
- Psychological Strategy Board, a U.S. government committee to coordinate psychological warfare
- Public security bureau (China), the name for a police department in mainland China
- Punjab & Sind Bank, Northern India (NSE: PSB)
Politics
- Belgian Socialist Party ()
- Brazilian Socialist Party ()
- United Sarawak Party, (), a political party in Sarawak, Malaysia
Science and medicine
- Persistent slip bands
- Phosphate solubilizing bacteria
- Protected specimen brush
- Purple sulfur bacteria
Technology
- Polysulfide–bromide battery
- Proton Synchrotron Booster, a synchrotron at CERN
- .PSB, an Adobe Photoshop file format
Other
- Mid-State Regional Airport (IATA airport code "PSB"), an airport in Philipsburg, Pennsylvania
- Polski Słownik Biograficzny, a Polish encyclopedia
- Poplar Street Bridge, a bridge across the Mississippi River
- Presidential Service Badge, of the US military
- Psychological Strategy Board, a committee set up by the Truman administration to coordinate and plan psychological operations
- Public service broadcasting in the United Kingdom
- Purple sprouting broccoli, a variety of broccoli