PPSh may refer to:
- PPSh-41, a Soviet World War II-era submachine gun with a drum or normal magazine
- PPS-43, a.k.a. PPS, a different Soviet World War II-era submachine gun
- Party of Labour of Albania, Partia e Punës e Shqipërisë, PPSh in Albanian
- Pseudovaginal perineoscrotal hypospadias
<!-- Long comment to avoid being listed on short pages -->