PFC may refer to:
Science and technology
- Perfluorinated compound, organofluorine compounds with hydrogen replaced by fluorine and other heteroatoms
- Perfluorocarbons, hydrocarbon derivatives containing only carbon and fluorine atoms
- Blood substitute, some of which are made of perfluorocarbons<!-- See: https://www.nytimes.com/1998/10/18/sports/a-new-threat-in-blood-doping.html -->
- Plasma-facing components, in a fusion reactor
- Prefrontal cortex, the anterior part of the frontal lobes of the brain
- Phonologie du Français Contemporain, French phonology research project
- Physiological functional capacity, the ability to perform the physical tasks of daily life
Technology
- Parallel flange channel, a type of steel beam
- Phase-fired controller, to control AC power
- Power factor correction, of electric loads
- Power foundation classes, computer libraries for PowerBuilder
- Priority flow control, Ethernet technology
Organizations
- Power Finance Corporation, an Indian financial institution
- PFC Energy, a global energy research and consultancy group
- Pacific Fur Company, a former fur trading venture
- Playing for Change, a multimedia music project
Sports
Association football
- Paris FC, France
- Paulínia FC, São Paulo, Brazil
- Persepolis F.C., Tehran, Iran
- PFC Beroe Stara Zagora, Bulgaria
- Portadown F.C., Northern Ireland
- Portstewart F.C., Northern Ireland
- Port F.C., Thailand
- Portsmouth F.C., England
- Pacific FC, Vancouver Island, Canada
- FK Partizan, Belgrade, Serbia<!--fails WP:DABACRO-->
Other sports
- Pillow Fight Championship, US professional sports organization
- Palace Fighting Championship, former US martial arts organization
- Pure Fusion Collective, a women’s stable in professional wrestling organization WWE
Other uses
- Passenger facility charge, a tax on air travelers
- Pacific City State Airport (IATA airport code), near Pacific City, Oregon, US
- Price forward curve, a method to determine the forecasted price of a commodity
- Private first class, a junior military rank