Ozona may refer to:
- Ozona, Florida, an unincorporated community
- Ozona, Texas, an unincorporated community, census-designated place and county seat
- Ozona High School
- Ozona Municipal Airport - see List of airports by IATA airport code: O
- Ozona Air Force Station, a former US Air Force radar station east of Ozona, Texas
- Ozona, a 2004 EP and a 2005 album by the English rock band Goldrush