Osama or Usama may refer to:
People
- Osama (name), an Arabic given name
- Osama bin Laden (1957–2011), Saudi Arabia-born Islamist dissident and militant leader who founded al-Qaeda
- Ōsama (born 1960), Japanese musician
Film
- Osama (film), a 2003 film made in Afghanistan
- Being Osama, a 2004 documentary film of six men named Osama
Other uses
- "Osama" (song), a 2021 single by Zakes Bantwini
- Dinner With Osama, a 2008 collection of short stories by Marilyn Krysl
- Osama (novel), a 2011 World Fantasy Award-winning novel by Lavie Tidhar
See also
- Ōsama Game, a Japanese 2011 horror film
- Osamu