Ord's thyroiditis is an atrophic form of chronic thyroiditis, an autoimmune disease where the body's own antibodies fight the cells of the thyroid.
It is named after the physician, William Miller Ord, who first described it in 1877 and again in 1888. It is more common among women than men. It has historically been separated from Hashimoto's Thyroiditis which presents with goiters, however some argue they each represent extremes of the same disease and should be classified together as a combined "Ord-Hashimoto’s disease".
Signs and symptoms
The first sign of Ord's thyroiditis is the atrophy of the thyroid gland from the start this can be identified by ultrasound. Another sign to help identify this disease is the presence of blocking anti-TSH receptors. Ord's thyroiditis can share symptoms with functional hypothyroidism.
Pathophysiology
Physiologically, antibodies to thyroid peroxidase and/or thyroglobulin cause gradual destruction of follicles in the thyroid gland. Accordingly, the disease can be detected clinically by looking for these antibodies in the blood. It is also characterized by invasion of the thyroid tissue by leukocytes, chiefly T-lymphocytes.
Treatment
Treatment is as with hypothyroidism, daily thyroxine(T4).
Epidemiology
Outside Europe a goitrous form of autoimmune thyroiditis (Hashimoto's Thyroiditis) is more common than Ord's disease.
See also
- Thyroiditis
- Hypothyroidism
- Hashimoto's thyroiditis
- Thyroxine
References
External links
de:Ord-Thyreoiditis