Operation Web Tryp was a United States Drug Enforcement Administration operation that ended on July 21, 2004 with the arrests of 10 persons. Its purpose was to investigate web sites suspected of distribution of unscheduled, unregulated tryptamines and phenethylamines of questionable legality. This trade in "grey market" drugs, which were not explicitly illegal but potentially prosecutable as drug analogs, became known as the "research chemical" trade; a euphemism to suggest that the chemicals were being sold for industrial or academic research rather than human consumption.
Five websites were involved in Operation Web Tryp. One of these websites, pondman.nu, was allegedly taking in U.S. $20,000 per week and grossed $700,000 before being shut down. Another, racresearch.com, reportedly grossed $500,000 in 14 months.
In 2005, a court ruled that AMT sold by pondman.nu caused the April 2002 death of an 18-year-old male in upstate New York and the site's owner was sentenced to 410 years in prison. No one was jailed and most were released without charge.