OWI may refer to:
- United States Office of War Information
- "operating while intoxicated", "operating while impaired", see Driving under the influence#Terminology
- Owi Airfield, Schouten Islands, Indonesia; a WWII USAAF airfield of the South West Pacific Theatre
- Ottawa Municipal Airport (FAA identifier <code>OWI</code>), KS, USA
- Owiniga language (ISO 639 language code <code>owi</code>)