OSM may refer to:
Software and websites
- OpenStreetMap, an open source project to develop free geographic data
- Open Service Mesh, a free and open source cloud native service mesh
Organizations
- Austrian Student Mission ()
- Office of Surface Mining, a branch of the US Department of the Interior
- OSM TV, a Bosnian commercial television channel
- Montreal Symphony Orchestra (), a Canadian symphony orchestra
Science
- Oncostatin M, a protein
- Osmole (unit), a unit of osmotic concentration
- Osmotic avoidance abnormal protein, for example OSM-9
Transportation
- Honda OSM, a 2008 Japanese concept sports car
- Mosul International Airport, Iraq, IATA airport code
- OS-M, a series of space launch rockets from OneSpace
Other uses
- Operational Service Medal (disambiguation), multiple campaign medals
- Order of the Secret Monitor, an appendant order of Freemasonry
- O.S.M., the post-nominal letters used by members of the Servite Order
- OSM Worldwide, a parcel delivery service
- One Saturday Morning, a former Saturday morning cartoon block on ABC