North Mesquite High School is a secondary school in Mesquite, Texas and a part of the Mesquite Independent School District (MISD). As of 2025, the school serves northern portions of Mesquite bounded by US 80 to the south and I-635 to the east in addition to the area bounded by Galloway Avenue, I-635, and I-30. Formerly, North Mesquite served all of Sunnyvale before the completion of Sunnyvale High School, leaving the class of 2010 the last North Mesquite class catering to Sunnyvale students. North Mesquite also formerly served the MISD portion of Garland before redistricting. This area is now served by Poteet High School.
North Mesquite serves grades 9 through 12. The total enrollment in 2002 was 2450; the school is therefore under the UIL AAAAAA (or 6A) division. According to the MISD Report Card, the per student expenditure for the same 2002 period was 2700 USD. The stallion is the school mascot and the school colors are blue and white. The school's motto is Animus Omnia Vincit, which translates from the Latin as "Courage Conquers All."
thumb|200px|North Mesquite High School before renovation
History
North Mesquite High School opened in September 1969 as the second high school in Mesquite ISD, behind Mesquite High School, the school's rival in athletic competitions. The original construction consisted of four floors: A, B, C, and D. Over several decades, the enrollment expanded in accordance with the population swell that took place in Mesquite and Sunnyvale, demanding supplementary facilities. In the 1990s, a new gym was constructed. F wing and E section opened for the 2002-2003 school year providing twenty new general classrooms as well as a new Band, Orchestra, and Choir hall. During the 2008-2009 school year construction on S wing (Science wing) began, and opened for the 2009-2010 school year providing 8 Labs and 16 science classrooms. With the science wing being added, the existing rooms on A floor were renovated and added new classrooms. The front of the school was renovated; a new entrance was created, and the business office was enlarged and renovated. The cafeteria was enlarged and snack lines were added. In September 2018 a statue of the school’s mascot, a Stallion, was placed inside the building right at the entrance.
thumb|200px|North Mesquite after renovation
thumb|200px|North Mesquite's New Entrance
Areas served by North Mesquite
North Mesquite serves northern portions of the city of Mesquite.
Formerly, the school also served all high school students living in Sunnyvale.