Nitsche is a surname. Notable people with the surname include:
- Dominik Nitsche, German professional poker player
- Joachim Nitsche (1926–1996), German mathematician
- Erik Nitsche, American graphic designer
- Francisco Nitsche, Chilean footballer
- Franz Nitsche, Austrian rower
- Heino Nitsche (1949–2014), German-American nuclear chemist
- Hinrich Nitsche, German zoologist
- Paul Nitsche (1876–1948), German psychiatrist executed for crimes against humanity
- Robert Lehmann-Nitsche, German anthropologist
See also
- Friedrich Nietzsche, whose last name is sometimes misspelt "Nitsche".
- Nietzsche (disambiguation)