Niobrara may refer to:
- Niobrara, Nebraska
- Niobrara County, Wyoming
- Niobrara River
- Niobrara National Scenic River
- Niobrara Formation, a geological unit
- Niobrara Township, Knox County, Nebraska
- Niobraran Sea, alternative name for the Western Interior Seaway, prehistoric inland sea in central North America
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