thumb|right|New River in Montgomery County, Virginia
Virginia's New River Valley region, colloquially named, is a four-county and one city area along the New River in Southwest Virginia in the United States, including such major features as Claytor Lake, part of the Jefferson National Forest, the city of Radford, the town of Blacksburg, and the New River, including the Pulaski terminus of the New River Trail State Park. Virginia's New River Valley brand is run by the economic development organization Onward New River Valley.
Local TV stations, regional organizations, tourism marketing promoters use the phrase to mean the counties of Giles, Pulaski, Montgomery and Floyd, the towns within them (e.g., Blacksburg), and the independent City of Radford, all located in the New River watershed. While Floyd County is not on the New River itself, it shares the Little River (New River tributary) with Montgomery and Pulaski.
Radford is nicknamed "The New River City," as it and the nearby Radford Arsenal are wrapped by bold loops in the river where it turns from flowing northeast to flowing northwest into West Virginia.
The "New River Valley" name is also used by other institutions in the region, including the New River Valley Community College and New River Valley Regional Jail, both in the Pulaski County town of Dublin, although they serve a wider region than the tourism-centered "NRV" promotions.