New Buffalo may refer to:
;Places in the United States
- New Buffalo, Michigan
- New Buffalo (Amtrak station), a train station in New Buffalo, Michigan
- New Buffalo Township, Michigan
- New Buffalo, Ohio, an unincorporated community
- New Buffalo, Pennsylvania
- New Buffalo (commune), commune in northern Taos County, New Mexico
;Other uses
- New Buffalo, former alias of musician Sally Seltmann, based in Melbourne, Australia
- New Buffalo (EP), an EP by New Buffalo