right|thumb|Mutt and Jeff as reprinted in All-American Comics #51 (1943).

Mutt and Jeff is a long-running American newspaper comic strip created by cartoonist Bud Fisher in 1907 about "two mismatched tinhorns". It is commonly regarded as the first daily comic strip. The concept of a newspaper strip featuring recurring characters in multiple panels on a six-day-a-week schedule had previously been pioneered through the short-lived A. Piker Clerk by Clare Briggs, but it was Mutt and Jeff as the first successful daily comic strip that staked out the direction of the future trend.

Mutt and Jeff remained in syndication until 1983, employing the talents of several cartoonists, chiefly Al Smith who drew the strip for nearly fifty years. The series eventually became a comic book, initially published by All-American Publications and later published by DC Comics, Dell Comics and Harvey Comics. Later it was also published as cartoons, films, pop culture merchandise and reprints. Its impact on popular culture is such that, even today, the phrase "Mutt and Jeff" is often used to jokingly refer to any pair of individuals of different sizes. In London, England, the phrase entered Cockney rhyming slang and is still in common usage as the term for “deaf”, although the etymology is now largely unknown (often written “mutton jeff”).

Syndicated success

Harry Conway "Bud" Fisher was a sports cartoonist for the San Francisco Chronicle in the early 1900s, a time when a newspaper cartoon was single panel. His innovation was to tell a cartoon gag in a sequence, or strip, of panels, creating the first American comic strip to successfully pioneer that since-common format. The concept of a newspaper strip featuring recurring characters in multiple panels on a six-day-a-week schedule actually had been created by Clare Briggs with A. Piker Clerk four years earlier, but that short-lived effort did not inspire further comics in a comic-strip format. As comics historian Don Markstein explained,