thumb|Facade of the Amparo Museum
The Museo Amparo, located in the historic center of Puebla City, is one of the most important historical museums in Mexico. It was inaugurated in 1991 and sponsored by the Amparo Foundation, which was founded in 1979 by Manuel Espinoza Yglesias in honor of his wife.
The museum is housed in two colonial-era buildings that date from the 17th and 18th centuries, which were popularly known as the Hospitalario. One of the buildings was the Hospital de Nuestra Señora y San Juan de Letrán founded in 1534. This building was made into a college for women by Bishop Juan de Palafox y Mendoza in the middle of the 18th century, and remained so until the 20th century. The other building is from the 18th century with a brick facade. It was part of the hospital for a time, then was converted into a “refuge” for married women. As a cultural center, the museum hosts temporary exhibits by national and international artists. It also presents conferences, seminars, concerts and workshops to support education, research and the creative arts.