Mizoguchi (written: 溝口 lit. "gutter/drain entrance") is a Japanese surname. Notable people with the surname include:
- Hajime Mizoguchi, musician
- , Japanese samurai and daimyō
- Kazuhiro Mizoguchi, javelin thrower
- Kenji Mizoguchi, filmmaker
- Koji Mizoguchi (born in 1963), Japanese archaeologist
- , Japanese daimyō
- , Japanese daimyō
- Noriko Mizoguchi, Japanese judoka
Fictional characters
- Hiroshi Mizoguchi, Hikaru no Go
- Mizoguchi Makoto, Fighter's History
- The main character of Yukio Mishima's novel Kinkaku-ji