A mitotoxin is a cytotoxic molecule targeted to specific cells by a mitogen. It is generally found in snake venom. Mitotoxins are responsible for mediating cell death by interfering with protein or DNA synthesis. Some mechanisms by which mitotoxins can interfere with DNA or protein synthesis include the inactivation of ribosomes These toxins have a very high affinity and level of specificity for the receptors that they bind to. Mitotoxins bind to receptors on cell surfaces and are then internalized into cells via receptor-mediated endocytosis. Once in the endosome, the receptor releases its ligand and a mitotoxin can mediate cell death. agents that can modulate the growth of melanomas.

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