Mikołaj Spytek Ligęza (c. 1562–1637) was a Polish–Lithuanian noble (szlachcic). He was castellan of Czechów, Żarnów, Sandomierz and was owner of Rzeszów.
He was son of Mikołaj Ligęza and Elżbieta Jordan.
He had two children: daughters Zofia Pudencjanna Ligęza and Konstancja Ligęza.