Mescalero is a main subdivision of the Apache Native American nation.

Mescalero may also mean:

  • Mescalero language
  • Mescalero, New Mexico, a census-designated place in the United States
  • Mescalero Ridge, an escarpment on the western edge of the Llano Estacado
  • The Mescaleros, Joe Strummer's back-up band
  • Mescalero (album), by ZZ Top
  • Cessna T-41 Mescalero, a 1960s vintage U.S. Air Force single-engine piston-prop primary flight trainer derived from the civil-market Cessna 172
  • Applebay GA-111 Mescalero, an American glider, of which one prototype was built in 1975