Melissus may refer to:
- Melissus of Samos, (fl. c. 500 BC), Greek philosopher
- Melissus of Thebes, Greek athlete contrasted to Orion by Pindar
- Gaius Maecenas Melissus (fl. early 1st century AD), Roman writer
- Paulus Melissus (1539–1602), humanist Neo-Latin writer, translator and composer
- Melisseus (or Melissus), father of the nymphs Adrasteia and Ida, the nurses of Zeus on Crete
- Melissus (another mythological figure), father of Actaeon; see Archias of Corinth
See also
- Melissaeus (disambiguation)