Mechanicsburg may refer to:
Places
In the United States:
- Mechanicsburg, Illinois
- Mechanicsburg Township, Sangamon County, Illinois
- Mechanicsburg, Boone County, Indiana
- Mechanicsburg, Henry County, Indiana
- Mechanicsburg, Ohio, in Champaign County
- Mechanicsburg, Crawford County, Ohio
- Mechanicsburg, Pennsylvania
- Mechanicsburg, Virginia
- Mechanicsburg, West Virginia
Fiction
- Mechanicsburg, a fictional European city in the comic series Girl Genius