thumb|An [[Eastern Orthodox Church|Eastern Orthodox cross]]

May 21 - Eastern Orthodox Church calendar - May 23

All fixed commemorations below celebrated on June 4 by Orthodox Churches on the Old Calendar.

For May 22nd, Orthodox Churches on the Old Calendar commemorate the Saints listed on May 9.

Feasts

  • Commemoration of the Holy Fathers of the Second Ecumenical Council (381)

Saints

  • Righteous Melchizedek, King of Salem (ancient Jerusalem) (c. 2000 BC)
  • Martyr Sophia the Healer, a physician, by beheading.
  • Martyr Marcellus, by being placed in molten lead.
  • Martyr Codratus (Quadratus), by being dragged by horses. <small>(see also: March 10)</small>
  • Martyr Basiliscus of Comana (c. 308) <small>(see also: March 3)</small>
  • Hieromartyrs Donatus, Bishop of Thmuis, the priest Macarius, and the deacon Theodore (c. 316)

Pre-Schism Western saints

  • Saint Ausonius, first Bishop of Angoulême (1st or 3rd century)
  • Saint Marcian of Ravenna, Bishop and Confessor (c. 127)
  • Martyrs Castus and Emilius, by fire, in Carthage (250)
  • Martyrs Timothy, Faustinus and Venustus, in Rome, under Julian the Apostate (362)
  • Saint Helen of Caernarfon (Elen Luyddog, lit. "Helen of the Hosts"), daughter of a Romano-British ruler, wife of Emperor Magnus Maximus, and a founder of churches in Wales (late 4th-century)
  • Saint Helen of Auxerre (c. 418)
  • Saint Julia of Corsica the martyr, who was crucified (440)
  • Saint Quiteria the virgin-martyr, in Spain (5th century)
  • Saint Romanus of Subiaco (Romanus of Auxerre), ascetic who ministered to Saint Benedict of Nursia (560)
  • Saint Fulk (c. 600)
  • Saint Conall (Conald, Coel), of Inniskeel (Inniscoel, Innis-coel), County Donegal, Abbot of the island monastery of Inniskeel (7th century)
  • Saint John of Parma, abbot of Saint John's at Parma from 973 to c. 982, then under Cluniac observance (c. 982)
  • New Hieromartyr Zachariah, priest of Prussa (1802)
  • Blessed James, youth, of Borovichi, Novgorod, Wonderworker (1540)
  • New Martyr Demetrios of Peloponnesos (1803) <small>(see also: April 14)</small>
  • Venerable Monk-martyr Paul of Mt. Athos, at Tripolis, Peloponnesus (1818)

New martyrs and confessors

  • Saint Innocent (Yastrebov), Archbishop of Astrakhan, Confessor (1928)
  • New Hieromartyr Maxim (Zhizhilenko), Bishop of Serpukhov (1931)
  • New Hieromartyr Michael Borisov, Archpriest, of Uglich (1942)

Other commemorations

  • Synaxis of the Cyprus Icon ("Sophianois" Icon) of the Most Holy Mother of God.
  • "Surety of Sinners" Icon of the Most Holy Theotokos, Korets (1622)
  • Repose of Eldress Macrina of Volos (Macrina of Portaria) (1995)